Role of arginase 1 immunohistochemical marker in differentiating hepatocellular carcinoma from other primary and secondary carcinomas of the liver, a tissue microarray study

: Hepatocellular carcinoma (HCC) is the most prevalent type of primary cancer liver in adults represent about 80%-90% all cancers. It essential to differentiate HCC and intrahepatic cholangiocarcinoma metastatic carcinoma. Arginase-1 was considered as sensitive specific marker benign malignant hepatocyte. This study aimed detect diagnostic role immunohistochemical expression arginase-1 differentiating From carcinomas comparison with hepatocyte paraffin antigen -1 (HepPar-1) Glypican 3. a retrospective performed on 117 cases, 77 cases were diagnosed HCC, 13 27 liver. Cases obtained from surgical pathology laboratory at Gastroenterology Center, Mansoura University, Egypt during period 2014 2017. All studied immunostained Arginase 1, Heppar 1and 1 expressed sensitivity (100%), while only case negative other specificity(97.5%), overall accuracy (99.1%). On side, 3 36 out (46.8%), 40 specificity (92.3%), (62.4%). 69 (89.6%), (100%). The 93.2%. accurate non liver, heppar second HepPar-1, are best markers regarding for small biopsies.